不同粒径参苈散超微粉和细粉溶出度比较

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目的:考察并比较参苈散细粉和超微粉的溶出度,为改进、提高药品的制备工艺提供依据。方法:以桨法制备供试品溶液,HPLC法测定红景天苷的含量,计算参苈散细粉和超微粉的溶出度。结果:参苈散超微粉的溶出度和溶出率均大于细粉。结论:微粉化有利于药物有效成分的溶出。 OBJECTIVE: To investigate and compare the dissolution of ginseng powder and superfine powder to provide basis for improving and improving the preparation technology of the drug. Methods: The test solution was prepared by paddle method. The content of salidroside was determined by HPLC, and the dissolution of ginseng powder and superfine powder was calculated. Results: Shen Tansu superfine powder dissolution and dissolution rate were greater than the fine powder. Conclusion: Micronization is conducive to the dissolution of the active ingredients of the drug.
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