肾上腺皮质激素已在临床上广泛应用于治疗结缔组织疾病、类风湿病、肾炎、血液病及器官移植等 ,并取得较好疗效。但是长期大剂量使用可引起严重并发症 ,近年来我们发现逐年有所增多现象。自 1980年至今我们收集 10例使用大剂量激素治疗后合并骨缺血坏死 ,现报道如下。1　临床资 Cortina hormone has been widely used in clinical treatment of connective tissue diseases, rheumatoid arthritis, nephritis, hematological diseases and organ transplantation, and achieved better results. However, long-term high-dose use can cause serious complications, in recent years we find that there is an increase year by year. Since 1980, we collected 10 cases of high-dose hormones combined with bone necrosis, are reported below. 1 clinical resources