The law of element segregation of Ti, N, Mn and S, and the sequence of selective precipitation of TiN and MnS inclusions during solidification of molten steel of SWRH82 A are studied on the basis of thermodynamics. The origin of large TiN inclusions which affect the titanium inclusions point penalty in SWRH82 A wire rod is analyzed based on the research on the distribution characteristics of MnS and large size of TiN inclusions observed on metallographic specimen of SWRH82 A steel wire rod. The solidification segregation ratio of Ti is far more than that of N, and the solidification segregation ratio of S is far more than that of Mn. In the range of cooling rate of the continuous casting production, the cooling rate of solidification has little effect on the segregation ratios of Ti, N, Mn and S. MnS inclusions will precipitate earlier than TiN inclusions during solidification of the molten steel of SWRH82 A. The large TiN inclusion which is wrapped by MnS in the SWRH82 A wire rod may be foreign inclusions and it is not precipitated product during solidification in the molten steel of SWRH82 A. The law of element segregation of Ti, N, Mn and S, and the sequence of selective precipitation of TiN and MnS inclusions during solidification of molten steel of SWRH82 A are studied on the basis of thermodynamics. The origin of large TiN inclusions which affect the titanium inclusions point penalty in SWRH82 A wire rod is analyzed based on the research on the distribution characteristics of MnS and large size of TiN inclusions observed on metallographic specimen of SWRH82 A steel wire rod. The solidification segregation ratio of Ti is far more than that of N, and the solidification segregation ratio of S is far more than that of Mn. In the range of cooling rate of the continuous casting production, the cooling rate of solidification has little effect on the segregation ratios of Ti, N, Mn and S. MnS inclusions will precipitate earlier than TiN inclusions during solidification of the molten steel of SWRH82 A. The large TiN inclusion which is wrapped by MnS in the SWRH82 A wire rod may be foreign inclusions and it is not precipitated product during solidification in the molten steel of SWRH82 A.