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目的通过对高龄孕妇产前诊断结果分析,探讨高龄妊娠与胎儿染色体异常的关系。方法对1139例≥35岁高龄孕妇进行胎儿染色体核型分析。结果 1139例高龄妊娠胎儿检出染色体异常33例,异常率2.90%,其中数目异常21例,包括21-三体14例、18-三体2例、45,XO 2例、47,XXY 2例、47,XYY 1例;结构异常12例,包括倒位6例、易位3例、异染色质增加1例、其他2例。35-39岁组染色体异常率2.31%,≥40岁组染色体异常率5.85%。结论随着孕妇年龄的增长,胎儿染色体异常率逐渐增高,有必要对高龄孕妇进行产前诊断。
OBJECTIVE: To analyze the prenatal diagnosis of elderly pregnant women to explore the relationship between the elderly pregnancy and fetal chromosomal abnormalities. Methods Fetal chromosome karyotype analysis was performed in 1139 pregnant women ≥35 years old. Results Of the 1139 fetuses with gestational age, 33 cases were detected abnormal chromosomes, the abnormality rate was 2.90%. Among them, 21 cases were abnormal in number, including 21 cases of trisomy 21, 2 cases of 18-trisomy, 2 cases of XO, 47 cases of XXY and 2 cases of XXY , 47 with XYY, and 12 with structural abnormalities, including 6 inversions, 3 translocations, 1 extra heterochromatin, and 2 other cases. 35-39 years old group chromosomal abnormalities 2.31%, ≥ 40 years old group chromosomal abnormalities 5.85%. Conclusion As the age of pregnant women increases, the rate of fetal chromosomal abnormalities gradually increases, so it is necessary to make prenatal diagnosis of pregnant women.