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目的:探讨肾结石负荷的3种测量参数(结石体积、结石最大径、结石面积)与输尿管软镜碎石术手术时间及效果的相关性。方法:回顾性分析2018年1月至2019年12月深圳市人民医院70例因单发肾结石行输尿管软镜碎石术患者的临床资料。男46例，女24例；年龄(47±12)岁。结石位于左侧28例，右侧42例；位于肾盂32例、下盏29例、中盏6例、上盏3例。70例均行输尿管软镜碎石术。记录手术时间。将术前CT图像导入ITK-SNAP 3.6.0软件半自动计算结石体积。采用术前CT平扫图像，在冠状面上选择结石最大截面，测量结石最大长径(D)和宽径(d)，结石面积＝0.25πDd。根据术后CT平扫结果将患者分为两组：残余结石最大径≤2 mm者为完全清除组，>2 mm者为部分清除组。分别对结石体积、结石最大径、结石面积与手术时间或效果的相关性进行分析，并进行简单线性回归分析，再通过前向逐步线性回归评估其他因素对手术时间的影响。结果:手术时间中位值63(50，84)min。完全清除组47例，结石体积633(248，1 087)mmn 3，结石最大径15(10，19)mm，结石面积82(49，186)mmn 2。部分清除组23例，结石体积696(408，1 418)mmn 3，结石最大径15(12，20)mm，结石面积105(73，201)mmn 2。两组结石体积、结石最大径、结石面积差异均无统计学意义(n P>0.05)。结石最大径>20 mm患者的完全清除率为55%(6/11)，结石最大径≤20 mm患者的完全清除率为70%(41/59)，两组差异无统计学意义(n P>0.05)。结石体积与手术时间的相关系数最大，为0.58，结石最大径和结石面积与手术时间的相关系数分别为0.33和0.34。结石体积与手术时间的简单线性回归的决定系数最优，为0.36,结石最大径、结石面积与手术时间的决定系数分别为0.17和0.22。手术时间与结石体积进行单因素线性回归后计算出的AIC基线值为456.24,采用前向逐步回归法依次加上结石最大径、结石成分、结石位置等因素后，AIC值依次增加至458.19、458.69、463.03。n 结论:结石体积、结石最大径和结石面积与输尿管软镜碎石术的结石清除率均无显著相关性，但结石体积是影响手术时间的最主要因素，是反映结石负荷的最佳参数。“,”Objective:To evaluate the best parameter of predicting the operation time and clearance of flexible ureteroscopic lithotripsy through comparing correlations between three stone burden parameters (diameter, area, volume) and the operation time or clearance retrospectively.Methods:Clinical data and CT images of 70 patients who performed flexible ureteroscopic lithotripsy because of single kidney stone in our center from January 2018 to December 2019 were retrospectively reviewed. There were 46 males and 24 females; their age was (47±12) years old. Stones were located on the left side in 28 cases and right side in 42 cases; 32 cases in the renal pelvis , 29 cases in the lower calyx, 6 cases in the middle calyx and 3 cases in the upper calyx. The free software ITK-SNAP 3.6.0 to segment kidney stones in 3D models with the CT image was used. The stone volume was calculated automatically after the segment. The largest section of the stone on the CT coronal plane was selected to measure the maximum length (D) and width (d) of the stone, the maximum diameter of the stone was D, and the stone area was calculated using the formula 0.25πDd. The patients were divided by the operation clearance into total clearance group and partial clearance group. The correlations between three stone burden parameters (volume, diameter, area) and operation time or clearance of the flexible ureteroscopic lithotripsy were compared. Simple linear regression model was also applied to compare three measurement methods. Then other factors which may affect the operation time was evaluated with the stepwise linear regression model, such as stone component and location.Results:The median operation time was 63(50, 84)min. Of 70 cases, 47 cases were in the stone-free group, with stone volume 633(248, 1 087)mmn 3, maximum diameter 15(10, 19)mm, and area 82(49, 186)mmn 2. 23 cases were in the non stone-free group, with volume 696(408, 1 418)mmn 3, maximum diameter 15(12, 20)mm, area 105(73, 201)mmn 2. There was no difference between the two groups in volume, maximum diameter and area of stones (all n P>0.05). The stone-free rate of the diameter >2 cm group was 55% (6/11), ≤2 cm group was 70% (41/59). There was no significant difference between the two groups. Correlation between stone volume and operation time is the best. The correlation coefficient of stone volume is 0.58, of stone diameter is 0.33, of stone area is 0.34. Coefficients of determination of the stone volume linear regression is the best, too. R square of stone volume is 0.36, of stone diameter is 0.17, of stone area is 0.22. Forward stepwise regression model shows stone volume is the most important parameter which correlate with operation time. None of stone volume, diameter or area has significant correlation with the clearance of stone.n Conclusion:Stone volume is the best predictive parameter of the stone burden because it has the best correlation with the operation time of the flexible ureteroscopic lithotripsy of the single kidney stone.