用移植人小细胞肺癌的裸鼠作为肿瘤模型,研究了碘标记单克隆抗体2F7在体内的肿瘤显fi,抗体、药物偶合物的连接,导向药物2F7-HSA-MTX的体外细胞毒及体内肿瘤抑制作用。结果显示,碘标记抗体在荷瘤小鼠体内有确切的肿瘤定位作用,清晰的肿瘤显像持续到168h以后。间接连接的导向药物可携带更多的MTX分子,细胞毒作用比直接连接提高2倍。导向药物可使荷瘤小鼠的长瘤潜伏期延长,长瘤率降低,抑瘤率为84％和自然生存期延长。 Using nude mice transplanted with human small cell lung cancer as a tumor model, tumorigenicity of iodine-labeled monoclonal antibody 2F7 in vivo, attachment of antibodies and drug conjugates, and in vitro cytotoxicity and tumor targeting of drug 2F7-HSA-MTX were investigated. Inhibition. The results showed that the iodine-labeled antibody had an exact tumor localization in tumor-bearing mice, and clear tumor imaging continued until 168 hours later. Indirectly linked drug-directed drugs can carry more MTX molecules with a cytotoxic effect that is two-fold higher than that of direct linkers. Targeted drugs can prolong the latency of long tumors in tumor-bearing mice, reduce the rate of prolonged tumors, inhibit the tumor growth rate by 84%, and prolong the natural survival period.