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目的 研究病毒载量检测和CD4 + 计数在评价人类免疫缺陷病毒 (HIV)感染者疗效中的应用效果。方法 对HIV感染者临床病例 73例进行了实验室和临床观察 ,其中包括 6例鸡尾酒治疗病例、36例中药试验性治疗病例及 31例未进行治疗的感染者。主要实验室指标包括血浆病毒载量及T淋巴细胞亚群计数。结果 在进行治疗后 3个月时联合治疗组的病毒载量明显低于其他两组 ,并且在其后保持在很低的水平 ,CD4 + 计数水平明显高于其他两组并在其后持续升高。在整个观察期间 ,中药治疗组的病毒载量检测和CD4 + 计数水平与未治疗组差异无显著性 ,但在临床症状观察中中药治疗组较未治疗组有明显改善。结论 病毒载量检测和CD4 + 计数试验是评价抗HIV治疗疗效的有效方法。
Objective To study the effect of virus load detection and CD4 + count in evaluating the efficacy of human immunodeficiency virus (HIV) infection. Methods 73 cases of HIV-infected patients were studied clinically and clinically, including 6 cases of cocktail treatment, 36 cases of experimental treatment of Chinese medicine and 31 cases of untreated infection. Major laboratory indicators include plasma viral load and T lymphocyte subsets counts. Results The viral load of the combination therapy group was significantly lower than that of the other two groups at 3 months after treatment, and remained very low thereafter, the CD4 + count was significantly higher than the other two groups and continued to rise thereafter high. During the whole observation period, there was no significant difference in the detection of viral load and CD4 + count between the Chinese medicine treatment group and the untreated group. However, in the observation of clinical symptoms, there was a significant improvement in the Chinese medicine treatment group compared with the untreated group. Conclusion The viral load test and CD4 + count test are effective methods to evaluate the anti-HIV treatment efficacy.