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目的:探讨兰索拉唑(Lan)在治疗幽门螺杆菌(Hp)阳性十二指肠球部溃疡(DU)中的作用.方法:62例经胃镜证实的Hp阳性DU患者,随机分成3组,分别接受Lan、Lan+克拉仙(Kla)、善胃得(Zan)治疗2周,2周后全部病人接服Zan4周.Lan30mg OM、KlaO.5Bid、Zan0.15Bid.疗程结束后复查胃镜.以尿素酶试验及组织切片判断Hp根除与否.结果:Hp根除率Lan+Zan组与Lan+Kla+Zan组有显著性差异,与Zan组无显著性差异;溃疡愈合率Lan+Zan组与Lan+Kla+Zan组无显著性差异,与Zan组有显著性差异;3组的症状改善情况无显著性差异.结论:兰索拉唑单用根除Hp效果不显著,其愈合溃疡、改善症状的效应,主要通过强力抑制胃酸分泌而达到.
Objective: To investigate the role of Lan in the treatment of Helicobacter pylori (Hp) -positive duodenal ulcer (DU) .Methods: Sixty-two Hp-positive DU patients confirmed by gastroscopy were randomly divided into three groups , Received Lan, Lan + Kla, Zan respectively for 2 weeks, and 2 weeks later all patients received Zan for 4 weeks.Lan30mg OM, KlaO.5Bid, Zan0.15Bid.Review gastroscopy after the end of treatment Urease test and histological section to determine whether Hp eradication.Results: There was a significant difference between Hp eradication rate Lan + Zan group and Lan + Kla + Zan group, but no significant difference with Zan group.The rate of ulcer healing in Lan + Zan group and Lan + Kla + Zan group, there was no significant difference between Zan group and Zan group.No significant difference was found in the improvement of symptoms among the three groups.Conclusion: Lansoprazole alone had no significant effect on eradication of Hp, healed ulcer and improved symptoms Effect, mainly through strong inhibition of gastric acid secretion and achieve.