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目的探讨胆碱能杀虫剂中毒后发生中间综合征(IMS)的相关危险因素。方法收集324例患者的一般临床资料包括年龄、性别、基础疾病,以及毒物类型、中毒途径、治疗方法、IMS的临床特征。观察IMS的发病率,并分析其相关危险因素。结果 16.4%患者发生IMS,死亡率39.6%,其中男性占66.7%,且年龄>45岁是IMS进展的显著危险因素[RR 2.67,95%CI(1.31,4.72),P<0.05],而多次洗胃则是保护因素[RR 0.35,95%CI(0.11,0.79),P<0.05]。结论 IMS的发生与年龄>45岁、洗胃次数多少相关,而与洗胃时机和毒物类型无关。
Objective To explore the related risk factors of intermediate syndrome (IMS) after cholinergic insecticide poisoning. Methods The general clinical data of 324 patients were collected, including age, gender, underlying diseases, types of poison, route of poisoning, treatment methods and the clinical features of IMS. The incidence of IMS was observed and its associated risk factors were analyzed. Results IMS occurred in 16.4% of the patients, with a mortality rate of 39.6%, of which 66.7% were male, and a significant risk factor for progression of IMS was 45 years (RR 2.67, 95% CI 1.31, 4.72, P <0.05) Second gastric lavage was a protective factor [RR 0.35, 95% CI (0.11, 0.79), P <0.05]. Conclusion The occurrence of IMS is related to the age> 45 years and the frequency of gastric lavage, but not to the timing of gastric lavage and the type of poison.