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目的探讨鳕鱼肝油对小鼠免疫功能的影响。方法 SPF级雌性昆明种小鼠200只随机分为五大组,每组分为4小组,分别为低、中、高3个剂量组和1个溶剂对照组,连续灌胃(20 ml/kg.体重)30 d后,测定脾淋巴细胞转化、迟发型变态反应、抗体生成细胞数量、血清溶血素水平、碳廓清原、腹腔巨噬细胞吞噬鸡红细胞能力和NK细胞活性等七项免疫指标。结果各剂量组的各项检测结果与阴性对照组比,均能刺激小鼠脾淋巴细胞增殖、转化作用;促进小鼠迟发型变态反应作用;提高小鼠抗体生成细胞数和血清溶血素水平,增强小鼠NK细胞活性。结论鳕鱼肝油具有增强小鼠免疫功能作用。
Objective To investigate the effect of cod liver oil on immune function in mice. Methods Two hundred SPF female Kunming mice were randomly divided into five groups, each group was divided into four groups, which were low dose, middle dose and high dose and one solvent control group. Body weight) 30 days later, seven immune indexes including splenic lymphocyte transformation, delayed-type allergy, antibody producing cell number, serum hemolysin level, carbofuran, peritoneal macrophage phagocytosis chicken erythrocytes and NK cell activity were measured. Results Compared with the negative control group, all the test results of each dose group could stimulate the proliferation and transformation of splenic lymphocytes in mice, promote delayed type hypersensitivity in mice, increase the number of antibody-producing cells and serum hemolysin in mice, Enhance mouse NK cell activity. Conclusion Cod liver oil can enhance the immune function in mice.