当前美国有近一半妊娠妇女用血清法筛查胎儿开放性神经管缺陷和Down综合征。根据母亲年龄结合甲胎蛋白(AFP)测定或联合其它指标如:绒毛膜促性腺激素(hCG)、uE_3和游离β-hCG等,大大改善了对Down综合征的认识,但仍需要更敏感、更有特异性的筛查方法。 1994年Cuckle报道了Down综合征妊娠的中期时母体尿促性腺激素肽(UGP)的β-中心片段明显增高。孕19～22周时UGP为 Currently, nearly half of pregnant women in the United States use serum screening for fetal open neural tube defects and Down syndrome. According to the age of the mother combined with AFP (AFP) or combined with other indicators such as: chorionic gonadotropin (hCG), uE_3 and free β-hCG, etc., greatly improved the understanding of Down syndrome, but still need more sensitive, More specific screening methods. In 1994, Cuckle reported that the β-center of the maternal urinary gonadotropin peptide (UGP) was significantly increased at the mid-third of pregnancy in Down syndrome. UGP 19 to 22 weeks pregnant