论文部分内容阅读
目的 为了解MTS1基因变异在头颈部肿瘤发生发展中的作用。方法 采用多重PCR技术扩增MTS1基因外显子 2。结果 本组MTS1基因外显子 2纯合子缺失的频率为 37.3 % (17/4 5 ) ,分化较好鳞癌MTS1基因缺失频率 31.5 % (6 /19)明显低于分化较差的鳞癌的 5 7.1% (8/14) ,但差异无显著性 (P >0 .0 5 )。结论 本研究提示MTS1基因变异与头颈部恶性肿瘤的发生发展有关
Objective To understand the role of MTS1 gene mutation in the development of head and neck tumors. Methods Multiplex PCR was used to amplify exon 2 of MTS1 gene. Results The frequency of deletion of exon 2 homozygote of MTS1 gene in this group was 37.3% (17/45). The frequency of MTS1 gene deletion in a well-differentiated squamous cell carcinoma was 31.5% (6/19) significantly lower than that of poorly differentiated squamous cell carcinoma. 5 7.1% (8/14), but the difference was not significant (P > 0.05). Conclusion This study suggests that MTS1 gene mutations are associated with the development of head and neck malignancy.