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目的了解女性系统性红斑狼疮(SLE)患者血清Th相关细胞因子水平,并探讨其与患者病情发生、发展的关系。方法用采用双抗体夹心法检测女性SLE患者Th1相关细胞因子IL-2、IFN-γ和Th2相关细胞因子IL-4、IL-10。结果SLE患者血清IL-2、IFN-γ水平显著低于正常对照组(P<0.05),IL-4、IL-10水平显著高于正常对照组(P<0.01)。IL-2、IFN-γ、IL-4、IL-10与ANA、C3、C4、CRP、ACA、抗ds-DNA抗体水平及SLEDAI活动性评分均无相关性,经治疗后IL-2、IFN-γ水平在治疗后升高,IL-4和IL-10水平较治疗前下降。结论SLE患者IL-4、IL-10水平明显高于健康对照组,IL-2、IFN-γ水平明显低于健康对照组,支持SLE患者体内存在Th1细胞向Th2细胞转化,表现为以Th2细胞为主的免疫应答。
Objective To investigate the level of serum Th related cytokines in female patients with systemic lupus erythematosus (SLE) and to explore its relationship with the occurrence and development of patients. Methods Th1-related cytokines IL-2, IFN-γ and Th2 related cytokines IL-4, IL-10 were detected in female SLE patients by double antibody sandwich method. Results The levels of IL-2 and IFN-γ in serum of SLE patients were significantly lower than those of normal controls (P <0.05). The levels of IL-4 and IL-10 in SLE patients were significantly higher than those in normal controls (P <0.01). The levels of IL-2, IFN-γ, IL-4 and IL-10 were not correlated with the levels of ANA, C3, C4, CRP, ACA, anti-dsDNA antibody and SLEDAI activity. -γ levels increased after treatment, IL-4 and IL-10 levels decreased compared with before treatment. Conclusions The levels of IL-4 and IL-10 in patients with SLE are significantly higher than those in healthy controls. The levels of IL-2 and IFN-γ in patients with SLE are significantly lower than those in healthy controls. Th1 cells in SLE patients are transformed into Th2 cells in the presence of Th2 cells Based immune response.