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AIM:To study the anti-tumor effect of resveratrol alone andthe synergistic effects of resveratrol with 5-FU on the growthof H_(22)cells line in vitro.METHODS:The number of cells was measured by MTTmethod,the morphological changes of H_(22)cells wereinvestigated under microscopy and electron microscopy.RESULTS:Resveratrol inhibited the growth of hepstomacells line H_(22)in a dose-and time-dependent manner.IC_(50)ofthe resveratrol on H_(22)cells was 6.57mg·L~(-1).The synergisticanti-tumor effects of resveratrol with 5-FU increased to agreater extent than for H_(22)cells treated with 5-FU alone(70.2% vs 28.4%)(P<0.05).Under microscope andelectron microscope,characteristics of apoptosis such astypical apoptotic bodies were commonly found in tumorcells in the drug-treated groups.CONCLUSION:Resveratrol can suppresses the growth of H_(22)cells in vitro,its anti-tumor activity may occur through theinduction of apoptosis.
AIM: To study the anti-tumor effect of resveratrol alone and the synergistic effects of resveratrol with 5-FU on the growth of H 22 cells line in vitro. METHODS: The number of cells was measured by MTT method, the morphological changes of H_ ( 22) cells were investigated under microscopy and electron microscopy .RESULTS: Resveratrol inhibited the growth of hepatic cells line H_ (22) in a dose-and time-dependent manner. IC_ (50) of the resveratrol on H_ (22) cells was 6.57 mg · L ~ (-1) .The synergisticanti-tumor effects of resveratrol with 5-FU increased to agreater extent than for H 22 cells treated with 5-FU alone (70.2% vs 28.4%) (P <0.05) .Under microscope andelectron microscope, characteristics of apoptosis such astypical apoptotic bodies were commonly found in tumor cells in the drug-treated groups. CONCLUSION: Resveratrol can suppresses the growth of H_ (22) cells in vitro, its anti-tumor activity may occur through the induction of apoptosis.