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溃疡性结肠炎(UC),简称溃结,是炎性肠病(IBD)的一种。它和克隆病(crohn’s discase,CD)一样,被目前称为难治性疾病。虽然比病确切病因未明,但与免疫、遗传因素有关,并且有细胞因子和炎性递质的参与在UC的发生、发展中起着重要的作用。国外发病率高于国内(尤其犹太白种人)。据说与饮食习惯有关(脂肪含量高)。美国曾报道,牛奶或奶制品亦为一重要的致敏因素。另外,感染、神经精神因素也是本病的诱发因素。UC活动时血中IFN—γ、IL-6及TNFα皆明显增高,若用抗-TFNα或抗-IL-6受体抗体治疗,则病情改善明显。本文就UC的发病机理和治疗现状作一综述。
Ulcerative colitis (UC), referred to as ulceration, is a type of inflammatory bowel disease (IBD). Like crohn’s discase (CD), it is currently referred to as a refractory disease. Although the exact cause of the disease is unknown, but with the immune, genetic factors, and the involvement of cytokines and inflammatory neurotransmitters play an important role in the occurrence and development of UC. The incidence in foreign countries is higher than that in China (especially Jewish white people). It is said that with the eating habits (high fat content). The United States once reported that milk or dairy products are also an important sensitizing factor. In addition, infection, neuropsychiatric factors are also the predisposing factors of this disease. UC activity in the blood of IFN-γ, IL-6 and TNFα were significantly increased, if anti-TNFa or anti-IL-6 receptor antibody treatment, the disease improved significantly. This article reviews the pathogenesis and treatment of UC.