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作者就以下五个方面的问题进行了讨论:(一)大多数肿瘤有染色体缺陷,通常表现为染色体缺失或易位:(二)染色体畸变之恒定性,如100%的恶性淋巴瘤具有第8,14对染色体易位;95%的脑膜瘤出现第22对染色体的单体性:(三)人类细胞恶变中染色体的作用机制;大多数白血病、淋巴瘤以及某些实体瘤中存在染色体易位并推论供体染色体即癌基因所在的断裂点可以决定肿瘤的类型。而受体染色体的位点与细胞控制失调有关;(四)讨论癌基因、脆弱点和癌变剂与染色体缺陷的关系;(五)对染色体、癌变
The author discusses the following five aspects: (a) Most tumors have chromosomal defects, usually expressed as chromosome deletions or translocations: (ii) Constancy of chromosomal aberrations, eg, 100% of malignant lymphomas have the 8th 14 pairs of chromosomal translocations; 95% of meningiomas have chromosome 22 haplotypes: (3) Chromosomal mechanisms of action in malignant human cells; chromosomal translocations in most leukemias, lymphomas, and certain solid tumors It is also deduced that the donor chromosome, the onset of the oncogene, can determine the type of tumor. The location of the receptor’s chromosomes is related to the imbalance of cell control; (4) To discuss the relationship between oncogenes, vulnerabilities and cancer agents and chromosomal defects; (5) on chromosomes, canceration