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昆明种小鼠感染日本血吸虫尾蚴10条,两个月后皮下注射二甲肼(DMH)20mg/Kg体重,每周一次,到第8周时大肠粘膜细胞~3H—TdR掺入率为493±18cpm/μgDNA—p,显著高于正常组动物(p<0.001)。注射DMH组动物的3~H—TdR掺入率于第10周才开始明显升高(594±15cpm/μgDNA—P),比血吸虫病合并DMH处理组晚两周。血吸虫病动物于感染尾蚴后21、25、29和35周共排出粪便总胆汁酸和脱氧胆酸13.0±0.39和2.23±1.00mg/kg体重/日,分别为对照组动物的131％和152％,两组动物之间差别非常显著(P<0.01)。但血吸虫病DMH处理组动物该两种酸排出量波动在对照组测定值的范围内。
Kunming mice were infected with 10 S. japonicum cercariae. Two months later, 20 mg/kg body weight of dimethyl hydrazine (DMH) was injected subcutaneously. Once a week, the rate of incorporation of ~3H-TdR in colon mucosa cells was 493±. The 18 cpm/μg DNA-p was significantly higher than that in the normal group (p<0.001). The 3H-TdR incorporation rate in the animals injected with DMH began to increase significantly at week 10 (594±15 cpm/μg DNA-P), two weeks later than the schistosomiasis plus DMH group. In schistosomiasis animals, fecal total bile acids and deoxycholic acid (13.0±0.39 and 2.23±1.00 mg/kg body weight/day) were excreted at 21, 25, 29, and 35 weeks after infection with cercariae, which were 131% and 152% of the control animals, respectively. There was a significant difference between the two groups of animals (P<0.01). However, in the schistosomiasis DMH treated animals, the two acid excretions fluctuate within the range of the control group.