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目的:分析前列地尔联合益肾化湿颗粒对糖尿病肾病患者血糖、血脂、肾功能以及尿足细胞相关蛋白的影响。方法:98例糖尿病肾病患者按抽签法分为对照组与实验组,各49例,对照组予以前列地尔治疗,实验组基于对照组加用益肾化湿颗粒治疗,比较两组疗效,糖化血红蛋白(Hb A1c)、血糖(FPG)、餐后2 h血糖低(2h PG),甘油三脂(TG)、总胆固醇(TC)、高密度脂蛋白(HDL-C)、低密度脂蛋白(LDL-C),血尿素氮(BUN)、肌酐(Cr)、β2微球蛋白(β2-MG)、胱抑素(Cys-C),尿足细胞标志蛋白(PCX)nephrin,安全性。结果:实验组总有效率高于对照组(P<0.05)。治疗后,两组Hb Alc、FPG、2h PG比较无差异(P>0.05)。实验组TG、TC、LDL-C、BUN、Cr、β2-MG、Cys-c、PCX、尿nephrin/尿Cr低于对照组(P<0.05)。实验组HDL-C高于对照组(P<0.05)。结论:前列地尔联合益肾化湿颗粒治疗对糖尿病肾病的疗效确切,可利于血糖、血脂、肾功能的改善,降低尿足细胞相关蛋白的浓度。
Objective: To analyze the effect of alprostinil combined with Yishen Huashi granule on blood glucose, blood lipid, renal function and urinary podocyte related protein in patients with diabetic nephropathy. Methods: Ninety-eight patients with diabetic nephropathy were divided into control group and experimental group according to the method of drawing lots, 49 cases in each group. The control group was treated with alprostadil. The experimental group was treated with Yishen Huashui Granules on the basis of control group. The curative effect, Hb A1c, FPG, 2h PG, TG, TC, HDL-C, LDL C, BUN, Cr, β2-MG, Cys-C, PCX nephrin, safety. Results: The total effective rate in experimental group was higher than that in control group (P <0.05). After treatment, there was no difference in Hb Alc, FPG and 2h PG between the two groups (P> 0.05). The levels of TG, TC, LDL-C, BUN, Cr, β2-MG, Cys-c, PCX and urinary nephrin / urine Cr in the experimental group were lower than those in the control group (P <0.05). HDL-C in experimental group was higher than that in control group (P <0.05). Conclusion: Alprostadil combined with Yishen Huashi Granule can effectively treat diabetic nephropathy and improve blood sugar, blood lipid and renal function, and decrease the concentration of urinary podocyte related protein.