目的:总结新生儿先天性十二指肠梗阻的发病基础及临床特点,探讨合适的治疗方法、预后及意义。方法:针对十二指肠梗阻的不同类型选用不同的手术方式,十二指肠隔膜者采用隔膜切除、横行缝合的方式;环状胰腺和十二指肠闭锁者,采用上端横切、下端纵切的菱形吻合法;肠旋转不良者采用Ladd手术方式。结果:32例患儿中治愈30例,死亡2例,合并脑瘫1例,治愈率为93.75%。结论:严重的十二指肠梗阻在胎儿期可通过B超发现“双泡征”提前确诊,生后出现频繁的呕吐应想到本病的可能,30%泛影葡胺上消化道造影是简单易行的确诊方式,手术是治疗的关键,治疗及时者预后良好。 Objective: To summarize the basic and clinical features of neonatal congenital duodenal obstruction and to explore the appropriate treatment, prognosis and significance. Methods: Different surgical methods were chosen according to different types of duodenal obstruction. Duodenal septum was excised with septum and transverse stitching method. The patients with annular pancreas and duodenal atresia were transected at the upper end and vertical at the lower end Cut the diamond anastomosis; bowel dysplasia by Ladd operation. Results: Thirty patients were cured and two died in 32 patients. One patient had cerebral palsy and the cure rate was 93.75%. Conclusions: Severe duodenal obstruction in the fetus can be found by “B double bubble sign” early diagnosis, frequent vomiting after birth should think of the possibility of this disease, 30% Is a simple and easy way of diagnosis, surgery is the key to treatment, timely treatment of patients with good prognosis.