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为研究多药耐受相关蛋白基因（ＭＲＰ）在人膀胱癌中的表达状况，采用免疫组化技术检测４７例初发膀胱癌，７例复发性膀胱瘤及７例正常膀胱粘膜组织标本ＭＲＰ的表达。结果显示初发膀胱癌中，ＭＲＰ总阳性率为 ４０． ４％，复发性膀胱癌 ＭＲＰ总阳性率为 ５７．１％，正常膀胱粘膜也有 ２８． ５％的表达率。高分级（Ｇ_３）膀胱癌较低、中分级（Ｇ_１、Ｇ_２）膀胱癌 ＭＲＰ表达阳性率显著降低。说明 ＭＲＰ表达率下降是肿瘤分化不良及恶化的结果。ＭＲＰ与ｍｄｒ１表达之间无明显关系，两种基因不存在共同调节，进一步研究这种差异的临床意义是很有必要的。
To study the expression of multidrug resistance associated protein (MRP) gene in human bladder cancer, immunohistochemistry was used to detect MRP in 47 cases of primary bladder cancer, 7 cases of recurrent bladder tumor and 7 cases of normal bladder mucosa expression. The results showed that primary positive bladder cancer, MRP total positive rate of 40. 4%. The total positive rate of MRP in recurrent bladder cancer was 57.1% and that in normal bladder mucosa was 28%. 5% expression rate. The positive rate of MRP in high grade (G_3) bladder cancer was lower than in middle grade (G_1, G_2) bladder cancer. The decrease of MRP expression is the result of poor differentiation and worsening of tumor. There is no significant relationship between MRP and mdr1 expression, and the two genes do not co-regulate. It is necessary to further study the clinical significance of this difference.