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目的:分析我院新生儿败血症的临床特征、实验室检查特点及危险因素,提高对该病的认识及治疗水平。方法:选择2009年2月至2012年2月入住我院新生儿病房的60例新生儿败血症患儿,其中早发型败血症(EOS)24例,迟发型败血症(LOS)36例。对患儿的临床特征、实验室检查特点等进行回顾性分析。结果:EOS多发生于足月儿和近足月早产儿(79.2%),LOS多发生于胎龄<34w的早产儿(50.0%)和极低出生体重儿(41.7%);LOS组患儿反应低下、喂养困难、呼吸困难的发生率明显高于EOS组(P均<0.05);EOS组白细胞增多、血小板减少、超敏C-反应蛋白(HsCRP)升高较LOS组多见(P均<0.05);两组患儿病原菌均以革兰阳性菌和条件致病菌为主,其中葡萄球菌最多,其次是大肠埃希菌、B族链球菌(GBS)。结论:早发型败血症多发生于足月儿,而迟发型败血症多见于早产儿和极低出生体重儿。
Objective: To analyze the clinical characteristics of neonatal sepsis in our hospital, laboratory features and risk factors to improve the understanding of the disease and the level of treatment. Methods: Sixty neonates with neonatal sepsis were admitted to neonatal ward of our hospital from February 2009 to February 2012, including 24 cases of early onset sepsis (EOS) and 36 cases of delayed sepsis (LOS). The clinical features of children, laboratory features such as a retrospective analysis. Results: EOS mostly occurred in term infants and premature infants (79.2%). LOS occurred mostly in preterm infants (50.0%) and very low birth weight infants (41.7% (P <0.05). The incidence of leukocytosis, thrombocytopenia and HsCRP in EOS group were higher than that in LOS group (P <0.05), and the incidence of dyspnea was lower than that in EOS group <0.05). The pathogens in both groups were mainly Gram-positive bacteria and opportunistic pathogens, of which Staphylococcus was the most common, followed by Escherichia coli and Streptococcus group B (GBS). Conclusions: Early onset septicemia occurs more frequently in term infants, whereas late onset septicemia is more common in preterm and very low birth weight infants.