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目的:探讨新生儿缺氧缺血性脑病(HIE)发病的相关危险因素,为早期防治HIE提供依据。方法:采用病例对照研究法,将确诊的130例HIE患儿作为病例组,随机抽取同期住院的130例非HIE新生儿作为对照组,对所有研究对象进行临床流行病学调查,采用单因素非条件Logistic回归分析和多因素非条件Logistic回归分析法分析HIE发病的危险因素。结果:多因素Logistic回归分析结果显示妊娠期高血压疾病(HDCP)(OR=5.613)、妊娠期糖尿病(GDM)(OR=3.511)、不规范产前检查(OR=3.647)、产程异常(OR=3.819)、胎盘异常(OR=5.109)、胎儿窘迫(OR=3.347)、羊水污染(OR=2.892)、新生儿窒息(OR=2.532)、Apgar评分(OR=0.643)为HIE发病的相关危险因素。结论:应针对HIE发病的相关危险因素制定相应的预防措施。
Objective: To explore the related risk factors of neonatal hypoxic-ischemic encephalopathy (HIE) and provide evidence for the prevention and treatment of HIE in the early stage. Methods: A case-control study was conducted. A total of 130 confirmed HIE children were selected as the case group, and 130 non-HIE newborns in the same period were randomly selected as the control group. All patients were investigated for clinical epidemiology using univariate Logistic regression analysis and multivariate non-conditional logistic regression analysis were used to analyze the risk factors of HIE. Results: Multivariate Logistic regression analysis showed that HDCP (OR = 5.613), gestational diabetes mellitus (OR = 3.511), abnormal prenatal care (OR = 3.647) (OR = 3.19), fetal distress (OR = 3.347), amniotic fluid contamination (OR = 2.892), neonatal asphyxia (OR = 2.532) and Apgar score factor. Conclusion: Corresponding preventive measures should be made according to the relevant risk factors of HIE.