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目的:探讨热休克蛋白70(HSP70)在人乳腺癌和胃癌中的表达及其意义。方法:应用免疫组织化学的方法对64例乳腺癌和55例胃癌组织中的HSP70进行检测。结果:(1)HSP70在乳腺癌和胃癌组织中的表达分别为78.13%,61.82%。(2)乳腺癌中HSP70的表达与乳腺癌的病理类型,淋巴结转移情况及年龄未发现显著差异(P>0.05)。(3)胃癌中HSP70的表达与肿瘤浸润深度、淋巴结转移有密切关系(P<0.05)。结论:HSP70在乳腺癌和胃癌中均呈较高水平表达,其中在胃癌中的表达与肿瘤浸润深度、恶性程度有密切关系,HSP70在乳腺癌和胃癌的发生发展中起重要作用。HSP70可能成为乳腺癌,胃癌的诊断指标之一。
Objective: To investigate the expression and significance of heat shock protein 70 (HSP70) in human breast cancer and gastric cancer. Methods: Immunohistochemistry was used to detect HSP70 in 64 cases of breast cancer and 55 cases of gastric cancer. Results: (1) The expression of HSP70 in breast cancer and gastric cancer was 78.13% and 61.82% respectively. (2) There was no significant difference in the expression of HSP70 between breast cancer and pathological type, lymph node metastasis and age (P> 0.05). (3) The expression of HSP70 in gastric cancer is closely related to the depth of tumor invasion and lymph node metastasis (P <0.05). Conclusion: HSP70 is highly expressed in both breast and gastric cancer. The expression of HSP70 in gastric cancer is closely related to the depth of tumor invasion and malignancy. HSP70 plays an important role in the development of breast cancer and gastric cancer. HSP70 may become one of the diagnostic indicators of breast cancer and gastric cancer.