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糖尿病病人广泛存在血管钙化,包括血管内膜钙化和中膜钙化。血管钙化是糖尿病病人心血管疾病发病率和死亡率的主要独立危险因子。血糖升高及糖基化终末产物增加、高胰岛素血症、氧化应激、脂质代谢紊乱、炎症、细胞凋亡和骨调节蛋白表达异常等是糖尿病患者易诱发血管钙化的主要因素,与血管钙化的发生发展密切相关。
Vascular calcification is widespread in patients with diabetes, including intimal calcification and mesial calcification. Vascular calcification is a major independent risk factor for cardiovascular morbidity and mortality in diabetic patients. Hyperglycemia and increased glycosylation end products, hyperinsulinemia, oxidative stress, lipid metabolism disorders, inflammation, apoptosis and aberrant expression of bone regulatory proteins are the main factors that lead to vascular calcification in diabetic patients, and Vascular calcification is closely related to the occurrence and development.