目的研究对比特比萘芬与氟康唑对白念珠菌性阴道炎真菌清除效果。方法抽选2013年9月—2014年10月收治的白念珠菌性阴道炎患者142例,随机数字表法将上述患者分为观察组n=71)和对照组(n=71),对照组给予氟康唑胶囊口服,150mg,每周1次,连用3周;观察组给予特比萘芬片饭后口服,250mg,每日一次,连用2周。嘱患者治疗期间保持良好卫生习惯,避免性生活,配偶有炎症者同时给予相应治疗,并于治疗结束后1个月、6个月复诊。根据临床症状、体征及真菌学检查评价临床疗效,复查阴道分泌物真菌镜检和培养念珠菌结果评价真菌学疗效。结果观察组治疗后、1个月、6个月时复诊临床疗效有效率分别为88.7%、73.2%、43.7%与对照组85.9%、76.1%、49.3%比较差异无统计学意义(P>0.05);观察组治疗后、1个月、6个月时复诊真菌学疗效有效率分别为53.5%、32.4%、26.8%与对照组60.6%、47.9%、31.0%比较差异无统计学意义(P>0.05);两组不良反应情况比较差异无统计学意义(P>0.05)。结论特比萘芬和氟康唑对白念珠菌性阴道炎均有良好的治疗效果,真菌清除效果好,安全性高,临床可根据患者病情及个体情况选择用药。 Objective To study the effect of terbinafine and fluconazole on fungal elimination of Candida albicans vaginitis. Methods 142 patients with Candida albicans vaginitis were selected from September 2013 to October 2014. The patients were divided into the observation group (n = 71) and the control group (n = 71) on the random number table. The control group Give fluconazole capsules orally, 150mg, once a week, once every 3 weeks; observation group was given terbinafine tablets orally after meals, 250mg, once daily for 2 weeks. Zhu Huanzhe maintain good health during treatment, to avoid sex, spouses have inflammation at the same time to give the appropriate treatment, and 1 month after the end of treatment, 6 months referral. According to clinical symptoms, signs and mycological examination to evaluate the clinical efficacy, review of vaginal secretions fungi microscopy and culture of Candida results to evaluate mycological efficacy. Results After treatment, the effective rates of clinical curative effect in observation group were 88.7%, 73.2% and 43.7% at 1 month and 6 months respectively, with no significant difference compared with those in control group (85.9%, 76.1%, 49.3%) (P> 0.05 ). After treatment, the efficacy rates of mycological treatment in observation group were 53.5%, 32.4% and 26.8% respectively at 1 month and 6 months, respectively, compared with 60.6%, 47.9% and 31.0% in control group (P > 0.05). There was no significant difference in adverse reactions between the two groups (P> 0.05). Conclusion Terbinafine and fluconazole have a good therapeutic effect on Candida albicans vaginitis, fungus removal effect is good, high safety, the clinical choice of medication according to the patient’s condition and individual circumstances.