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目的:观察阻塞性睡眠呼吸暂停低通气综合征(OSAHS)患者采用UPPP加舌骨悬吊术治疗前后血栓素B2(TXB2)、肾素、血管紧张素Ⅱ(AT-Ⅱ)、内皮素1(ET-1)和抗心磷脂抗体(ACA)的变化及手术对其的作用。方法:选择经PSG检查确诊的重度OSAHS患者54例,为OSAHS组,另设对照组20例,用酶联免疫吸附试验检测两组TXB2、肾素、AT-Ⅱ、ET-1及ACA,OSAHS组手术治疗后半年复查上述指标。结果:OSAHS组术前血浆TXB2、肾素、AT-Ⅱ、ET-1及ACA均高于对照组(P<0.05或P<0.01);OSAHS组手术治疗后半年上述指标均低于术前(P<0.05或P<0.01);TXB2、肾素、AT-Ⅱ、ET-1、ACA与AH I呈正相关,与SaO2呈负相关。结论:OSAHS患者易患血栓栓塞性疾病,并与夜间低氧血症密切相关,手术治疗可有效逆转上述改变。
Objective: To observe the effects of UPPP plus hypospadias on the levels of TXB2, AT, and ET-1 in obstructive sleep apnea-hypopnea syndrome (OSAHS) ET-1) and anti-cardiolipin antibodies (ACA) changes and the role of surgery. Methods: Fifty-four patients with severe OSAHS diagnosed by PSG were selected as OSAHS group and 20 as control group. The levels of TXB2, renin, AT-Ⅱ, ET-1 and ACA, OSAHS in both groups were detected by enzyme linked immunosorbent assay Group after six months of surgical treatment of these indicators review. Results: Before operation, the levels of TXB2, renin, AT-Ⅱ, ET-1 and ACA in OSAHS group were significantly higher than those in control group (P <0.05 or P <0.01) P <0.05 or P <0.01). TXB2, renin, AT-Ⅱ, ET-1 and ACA were positively correlated with AHI and negatively correlated with SaO2. Conclusion: Patients with OSAHS are predisposed to thromboembolic disease and are closely related to nocturnal hypoxemia. Surgical treatment can effectively reverse these changes.