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农药的毒性作用,可以用各种方式表示农药对一些酶的影响就是其中之一。一些研究证实氨基甲酸酯类农药可导致细胞色素P-450及一些微粒体酶含量的变化。本文报道了最广泛使用的氨基甲酸酯类农药西维因和残杀畏对大鼠肝脏中细胞色素c还原酶活性和细胞色素P-450含量的亚急性作用。实验用大鼠,体重150～200 g,将西维因(6和12 mg/kg)、残杀畏(1和2 mg/kg)溶解于葵花籽油中,经口给药,2 ml/kg,共30天。对照组动物接受相应量的葵花籽油。给药后于第5、10、20、30天测定肝微粒体中细胞色素c还原酶活性和细胞色素P-450含量。用Nekovic的方法(1973)从实验组和对照组动
The toxic effects of pesticides, which can be used in a variety of ways to indicate the impact of pesticides on some enzymes is one of them. Some studies have confirmed that carbamate pesticides can cause changes in the content of cytochrome P-450 and some microsomal enzymes. This article reports the subacute effects of the most widely used carbamate pesticide, civenx and febilisate, on cytochrome c reductase activity and cytochrome P-450 content in rat livers. Experimental rats, weighing 150-200 g, were dissolved in sunflower oil at doses of 6 and 12 mg / kg and DDC (1 and 2 mg / kg), orally, 2 ml / kg , A total of 30 days. Control animals received the corresponding amount of sunflower oil. The cytochrome c reductase activity and cytochrome P-450 content in liver microsomes were determined on the 5th, 10th, 20th and 30th day after administration. Nekovic method (1973) from the experimental group and control group