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目的：研究、探讨不同剂量来非司酮用于紧急避孕的效果。方法：将未保护性生活后72h内要求紧急避孕的健康妇女共543人次随机分为4组。组1：单次口服来非司酮100mg，组2：单次口服米非司酮50mg，组3：单次口服术非司酮25mg，组4：单决口服来非司酮10mg。结果：组1、组2均无妊娠，组3妊娠2例，组4妊娠8例，各组避孕有效率相比，组1，2．3之间差异无显著性意义（P＞0．05），组1，2，3与组4间差异极显著（P＜0.01）。组1副反应发生率明显高于其他3组。结论：单次口服来非司酮50mg或25mg的紧急避孕效果显好。
Objective: To study and investigate the effect of different doses of nifepristone for emergency contraception. METHODS: A total of 543 healthy women requiring emergency contraception within 72 hours of unprotected life were randomly assigned to 4 groups. Group 1: a single oral administration of nifepristone 100mg, group 2: a single oral mifepristone 50mg, group 3: a single oral administration of pirpristone 25mg, group 4: single oral administration of nifepristone 10mg. Results: Group 1 and group 2 had no pregnancy, group 3 had 2 pregnancies, group 4 had 8 pregnancies. There was no significant difference in contraceptive effectiveness between groups 1 and 2 (P> 0.05 ). There was significant difference between groups 1, 2 and 3 (P <0.01). Group 1 side effects were significantly higher than the other three groups. CONCLUSIONS: A single oral administration of 50 mg or 25 mg of nifeprist provides good results in emergency contraception.