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受体酪氨酸蛋白激酶是细胞信号转导的关键分子之一,在细胞生长、分化中起重要作用,Eph作为其最大亚族,与其配体Ephrin结合能诱发双向信号转导过程,在参与许多生理过程的同时,一定条件下可促进细胞恶性转化、肿瘤浸润及转移。研究表明,EphA2及其配体EphrinA-1在恶性肿瘤新生血管形成及侵袭、转移中起非常重要的作用[1-3]。目前国内外有关EphA2及EphrinA-1的作用及表达的相关研究较少。本研究探讨EphA2及其配体EphrinA-1
Receptor tyrosine kinase is one of the key cell signal transduction molecules, plays an important role in cell growth and differentiation. As the largest subfamily of Eph, Eph and its ligand Ephrin can induce bidirectional signal transduction. Many physiological processes at the same time, under certain conditions can promote malignant transformation, tumor invasion and metastasis. Studies have shown that EphA2 and its ligand EphrinA-1 in malignant neovascularization and invasion, metastasis play a very important role [1-3]. At present, there are few researches on the role and expression of EphA2 and EphrinA-1 at home and abroad. This study explored EphA2 and its ligand EphrinA-1