目的:观察急性脑梗死应用尿激酶(UK)静脉溶栓治疗的疗效和安全性。方法:对120例急性脑梗死患者进行UK溶栓治疗并与对照组60例对比。结果:溶栓治疗组首次溶栓治疗后、3d、5d的神经功能缺损评分与对照组比较有显著差异(P<0.01),而14d有极显著差异(P<0.001);溶栓治疗组首次溶栓前后血纤维蛋白原有显著差异(P<0.01),而对照组无变化;两组治疗后14d疗效比较,有效率A组为83.33%,B组为50.00%,两组间有显著差异(P<0.01)。结论:UK治疗急性脑梗死安全、可靠。 Objective: To observe the efficacy and safety of intravenous thrombolysis with urokinase (UK) in acute cerebral infarction. Methods: Thrombolytic therapy was performed in 120 patients with acute cerebral infarction and compared with 60 patients in the control group. Results: Thrombolytic therapy group after thrombolytic therapy, 3d, 5d neurological deficit score compared with the control group were significantly different (P <0.01), and 14d were significantly different (P <0.001); Thrombolysis group for the first time Before and after thrombolytic fibrinogen were significantly different (P <0.01), while the control group no change; two groups 14d after treatment efficacy, the effective rate was 83.33% in group A, B was 50.00%, there was a significant difference between the two groups (P <0.01). Conclusion: UK treatment of acute cerebral infarction safe and reliable.