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目的 :探讨P 选择素、血小板激活因子水平变化在急性脑梗死时的意义。方法 :用ELISA法测定 3 0例急性脑梗死及对照组2 0例恢复期脑梗死患者的P 选择素、PAF水平 ,同时测定末梢血白细胞计数、中性粒细胞百分比及计算机体层摄影显示脑梗死面积。结果 :急性脑梗死患者的可溶性P 选择素、血小板激活因子明显增高 ,可溶性P 选择素、血小板激活因子水平与末梢血白细胞计数、中性粒细胞百分比、急性脑梗死的面积呈正相关。结论 :可溶性P 选择素、血小板激活因子是急性脑梗死病情监测和预后的指标
Objective: To investigate the significance of P-selectin and platelet activating factor in acute cerebral infarction. Methods: The levels of P-selectin and PAF in 30 patients with acute cerebral infarction and 20 patients with convalescent cerebral infarction in the control group were determined by ELISA. The peripheral blood leukocyte count, neutrophil percentage and computed tomography were also measured. Infarct size. Results: Soluble P-selectin and platelet activating factor were significantly increased in patients with acute cerebral infarction. Soluble P-selectin and platelet activating factor were positively correlated with peripheral blood leukocyte count, neutrophil percentage and area of acute cerebral infarction. Conclusion: Soluble P-selectin and platelet activating factor are indicators of the monitoring and prognosis of acute cerebral infarction