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目的:观察硝苯地平控释片对高血压病患者血清氧自由基的影响。方法:应用硝苯地平控释片对60例高血压病(EH)患者治疗12周,观测治疗前后血清超氧化物歧化酶(SOD)活力、脂质过氧化物(LPO)水平。结果:EH患者SOD活力较正常人明显下降,LPO水平明显升高;服药后患者SOD活力明显回升,LPO含量显著降低。结论:硝苯地平控释片具有抗氧自由基和保护SOD活性作用。
Objective: To observe the effect of nifedipine GITS on serum free oxygen in patients with essential hypertension. Methods: Sixty patients with essential hypertension (EH) were treated with nifedipine GITS for 12 weeks. The levels of serum superoxide dismutase (SOD) and lipid peroxidation (LPO) were measured before and after treatment. Results: The activity of SOD in EH patients was significantly lower than that in normal subjects, and the level of LPO was significantly increased. The SOD activity in patients with EH significantly increased and the content of LPO decreased significantly. Conclusion: Nifedipine GITS has antioxidant free radical and SOD activity.