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众所周知,不同人群服用同一剂量药物在药效和毒性反应上可能出现较大差异,因而在少数病人中会出现不可预测并危及生命或致死的不良反应。这种个体化差异不能完全被肝肾功能、年龄、生活方式或合并用药及病人依从性等因素来很好地解释,此时遗传因素或许是药物疗效和毒性的重要决定因素。遗传药理学研究目的就是将这些遗传因素鉴别清楚,根据个体基因变异与药效差异的关系设计临床个体化用药方案,以保证临床用药的安全、有效和经济。
It is well-known that different groups of people taking the same dose of drugs may have significant differences in pharmacodynamics and toxicity. Therefore, unpredictable and life-threatening or lethal adverse reactions may occur in a few patients. This individualized difference can not be completely explained by factors such as liver and kidney function, age, lifestyle or combination medication and patient compliance, at which time genetic factors may be important determinants of drug efficacy and toxicity. The purpose of genetic pharmacology research is to identify these genetic factors clearly, and to design clinical individualized drug regimens according to the relationship between individual genetic variation and pharmacodynamic differences so as to ensure the safety, effectiveness and economy of clinical medication.