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药理消化道与呼吸道是比较容易吸收的道路,铅由胃肠道吸收后,大部分仍经肝脏重新排到十二指肠。但由呼吸道吸入的铅尘,则迅速进入血循环而分布於全身各部。铅为蓄积性毒品,吸收后不久,即以不溶性磷酸盐沉积於骨中。一旦新陈代谢发生变化,骨中的铅重新侵入血流,到达一定的程度,即发生中毒症状。铅的代谢与钙相平行,任何能使钙在骨中沉积的因素,亦必能使铅沉积,同样,能使钙质由骨游离入血之因素,亦必能影响铅。这点在治疗铅中毒病例时非常重要。肠与肾是铅的排泄脏器,由肾排泄的量约为肠子的2.5倍。?
Pharmacological digestive tract and respiratory tract is relatively easy to absorb the road, lead absorbed by the gastrointestinal tract, most of the liver is still re-discharged to the duodenum. However, lead dust inhaled by the respiratory tract rapidly enters the blood circulation and is distributed throughout the body. Lead is an accumulative drug, absorbed shortly after it is deposited as insoluble phosphate in the bone. Once the metabolism changes, the bone in the lead again into the bloodstream, to a certain extent, that is, symptoms of poisoning. The metabolism of lead is paralleled with calcium. Anything that causes calcium to deposit in the bone will also lead to lead deposition. Similarly, factors that allow calcium to enter the bloodstream from the bone will also affect lead. This is very important when treating lead poisoning cases. Intestinal and kidney excretion of lead organs, the amount of excretion by the kidney about 2.5 times the intestine. ?