人类补体C8是组成膜攻击复合物(MAC)的五种成分之一。C8α、C8β与C6、C7、C9具有较强的同源性,而C8γ则属于分泌性蛋白家族成员,具有与小的疏水性配体结合的能力。形成膜攻击复合物的其他补体成分与C8的结合位点大多位于α、β的MACPF结构域。目前,大多数关于补体成分的研究主要集中于补体C3,鉴于补体C8在形成MAC中的重要性,在此就C8的结构与功能予以综述。 Human complement C8 is one of five components that make up the membrane attack complex (MAC). C8α, C8β and C6, C7, C9 has a strong homology, and C8γ belongs to the secretory protein family members, with a small hydrophobic ligand binding capacity. The other complement components that form the membrane attack complex are mostly located in the α, β MACPF domain with the C8 binding site. At present, most studies on complement components have focused on complement C3. Given the importance of complement C8 in MAC formation, the structure and function of C8 are reviewed here.