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业已证明乙胺嘧啶和磺胺类药联合治疗急性弓形体病性视网膜炎有效,此药能抑制急性弓形体病性视网膜炎病变内的鼠弓形体滋养体的增殖,但对慢性病的包囊缓殖子(encysted bradyzoites)无效,由于此缺点以及乙胺嘧啶本身有毒性作用,故有必要寻找更存效和毒性低的药物。作者指出二甲胺四环素(minocycline)对弓形体病有效应。此药系半合成四环素,通过阻止tRNA(转移核糖核酸)结合mRNA(信使核糖核酸)核糖体复合物而抑制微生物蛋白质的合成。它有广谱抗菌作用,并对氯喹有抗药性的恶性疟有疗效。该药能有效地根除鼠弓形体病,因此作者等用兔眼弓形体病模型估价此药的效果。
It has been shown that pyrimethamine and sulfonamides are effective in the treatment of acute toxoplasmic retinitis and this drug can inhibit the proliferation of T. gondii trophozoites in acute toxoplasmic retinitis lesions, Because of this shortcoming and the toxic effects of pyrimethamine itself, it is necessary to look for drugs with more effective and less toxic properties. The authors note that minocycline is effective for toxoplasmosis. This drug is a semi-synthetic tetracycline that inhibits microbial protein synthesis by preventing the tRNA (transfer RNA) from binding to the mRNA (messenger ribonucleic acid) ribosome complex. It has a broad spectrum antibacterial effect and is effective against chloroquine-resistant falciparum malaria. The drug can effectively eradicate toxoplasmosis, so the author used the rabbit eye toxoplasmosis model to evaluate the effect of this drug.