近年来,经鼓室局部给药已经成为治疗多种内耳疾病的新方法之一,该技术的主要理论依据是:药物与圆窗膜接触后,可不经过血-迷路屏障,直接经圆窗膜渗透进入内耳,并获得较全身用药更高的内耳药物浓度和持续时间[1~5],且可直接作用于患耳,避免全身用药的副作用。药物作用的靶组织包 In recent years, local administration through the tympanic cavity has become one of the new methods for the treatment of various inner ear diseases. The main theoretical basis of the technique is that after the drug contacts the round window membrane, it can penetrate directly through the round window membrane without passing through the blood-labyrinth barrier Into the inner ear, and access to higher systemic drug drug content and duration of the inner ear [1 ~ 5], and can be directly affected ear, to avoid systemic side effects. Drug target tissue package