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铂络合物的抗肿瘤作用近年来很受注意,顺氯氨铂(Cis-Dichloro-diamino-Platinum,DDP)巳在临床应用.我所及其他单位进行了国产顺氯氨铂的抗肿瘤作用及药理研究,该药经国内临床试用后,已于1976年底在广东省佛山市鉴定投产.近来,国外注意力集中于二价铂,而对四价铂络合物研究不多,并认为四价铂要还原形成活性二价铂络合物而起作用.最近Tobe发现某些二羟基四价铂络合物具有较高水溶性和抗瘤活性,引起了普遍的重视.
The anti-tumor effect of platinum complexes has received much attention in recent years. Cis-Dichloro-diamino-Platinum (DDP) has been used clinically. Our institute and other units have carried out the anti-tumor effect of domestic cisplatin. In pharmacological research, the drug was tested and put into production in Foshan City, Guangdong Province, at the end of 1976. Recently, foreign attention has focused on bivalent platinum, while little research has been done on tetravalent platinum complexes, and Valence platinum has to work to reduce the formation of active divalent platinum complexes. Recently Tobe discovered that certain dihydroxytetravalent platinum complexes have higher water solubility and antitumor activity, which has attracted widespread attention.