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目的观察醒脑静注射液对脑出血合并肺部感染患者神经功能、凝血功能和炎性指标的影响。方法选择2014年5月-2016年5月医院住院治疗的126例脑出血合并肺部感染患者作为研究对象,将患者随机分为对照组和观察组,每组各63例;对照组采用西医常规治疗,观察组在对照组基础上采用醒脑静注射液治疗,比较两组患者的疗效以及神经功能、凝血功能和炎性指标变化。结果观察组总有效率为81.0%,显著高于对照组的58.7%(χ~2=7.385,P=0.007);观察组治疗后NIHSS评分明显升高(P<0.05),GCS评分明显下降(P<0.05),与同期对照组比较差异均有统计学意义(P<0.05);观察组治疗后纤维蛋白原水平明显升高(P<0.05),D二聚体水平明显下降(P<0.05),与同期对照组比较差异均有统计学意义(P<0.05);两组治疗后IL-1β、IL-6、IL-8、IL-10和TNF-α水平均明显下降(P<0.05),且观察组低于对照组水平,差异均有统计学意义(P<0.05)。结论醒脑静注射液对脑出血合并肺部感染患者进行治疗,能够明显提高临床疗效,改善患者神经功能和凝血功能状态,同时抑制炎性反应,值得临床推广应用。
Objective To observe the effect of xingnaojing injection on neurological function, coagulation function and inflammatory index in patients with cerebral hemorrhage complicated with pulmonary infection. Methods From May 2014 to May 2016, 126 patients with cerebral hemorrhage complicated with lung infection hospitalized in our hospital were selected as the research object. The patients were randomly divided into control group and observation group, 63 cases in each group. The control group was treated with routine western medicine The treatment group and the observation group were treated with Xingnaojing injection on the basis of the control group. The curative effect, nerve function, coagulation function and inflammatory index of the two groups were compared. Results The total effective rate in observation group was 81.0%, significantly higher than that in control group (χ ~ 2 = 7.385, P = 0.007). NIHSS score in observation group increased significantly (P <0.05) and GCS score decreased significantly (P <0.05). Compared with the control group at the same period, the difference was statistically significant (P <0.05). The level of fibrinogen in the observation group was significantly increased (P <0.05) ), Compared with the control group at the same period (P <0.05). The levels of IL-1β, IL-6, IL-8, IL-10 and TNF- ), And the observation group was lower than the control group, the difference was statistically significant (P <0.05). Conclusion Xingnaojing injection in patients with intracerebral hemorrhage complicated with pulmonary infection can significantly improve clinical efficacy, improve neurological function and coagulation function, inhibit inflammatory reaction and deserve clinical application.