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目的:探讨三金三子汤免煎方剂中药对尿路结石形成机制的影响。方法:采用45Ca-CaCl2掺入的结晶生长动力学模型,研究不同作用时间免煎方剂中药对草酸钙结晶生长的影响。结果:从免煎方剂中药组5min滤液内cpm%明显减少,与对照组同时间点的水平相当,20~120min诸时间点的cpm%与对照组比较,cpm%减少幅度甚小,甚至接近回复总放管水平。结论:免煎方剂中药对草酸钙结晶生长有明显的抑制作用,抑制作用与用药时间呈依赖关系。为临床应用此免煎方剂中药临床治疗尿路结石患者提供一定的试验依据。
Objective: To investigate the effect of Sanjin Sanzi decoction on the formation of urolithiasis. Methods: The crystal growth kinetics model of 45Ca-CaCl2 was used to study the effects of different decoction-free Chinese herbs on the growth of calcium oxalate crystals. Results: Compared with the control group, the cpm% in the 5min filtrate of the decoction-free Chinese medicine group was significantly reduced at the same time point as that of the control group. The cpm% reduction at all time points of 20 ~ 120min was very small or even close to the recovery The total discharge level. Conclusion: Decoction-free Chinese herbal medicine has significant inhibitory effect on the growth of calcium oxalate crystals, and the inhibitory effect depends on the time of administration. This clinical trial of this decoction-free Chinese medicine for the treatment of urinary tract stones provides some experimental evidence.