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酰基辅酶A胆固醇酰基转移酶目前认为是细胞内唯一合成胆固醇酯的酶,维持着细胞以及生物体胆固醇代谢的平衡,而酰基辅酶A胆固醇酰基转移酶-1在动脉粥样硬化的发生、发展过程中发挥着至关重要的作用。自从酰基辅酶A胆固醇酰基转移酶的cDNA在1993年首次被克隆之后,许多学者对酰基辅酶A胆固醇酰基转移酶-1进行了大量的研究,现就近年来酰基辅酶A胆固醇酰基转移酶-1与动脉粥样硬化关系的研究予以综述。
Acyl-CoA cholesterol acyltransferase is currently considered to be the only intracellular cholesterol ester synthesis enzyme, maintaining the balance of cells and organisms cholesterol metabolism, and acyl-CoA cholesterol acyltransferase -1 in the occurrence and development of atherosclerosis Play a vital role. Since acyl-CoA cholesterol acyltransferase cDNA was cloned for the first time in 1993, many scholars have done a lot of research on acyl-CoA cholesterol acyltransferase-1. In recent years, acyl-CoA cholesterol acyltransferase-1 and arterial The relationship between atherosclerosis is reviewed.