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目的对不同时点输尿管梗阻再通术后肾功能恢复情况做动态观察。方法将24只犬随机分成3组,行左输尿管结扎制作输尿管梗阻模型。分别在梗阻后第1、4、8周行输尿管再通术,于梗阻术前、后及再通术后2周、4个月进行放射性核素(99mTc-DTPA)显像,观察梗阻肾功能恢复的影像变化,并计算肾小球滤过率。结果输尿管梗阻1周组犬行再通术后肾功能可完全恢复到正常水平;4周组犬行再通术后肾功能仅能有部分恢复;8周组犬行再通术后未观察到肾功能恢复。结论输尿管梗阻时间是影响犬肾功能恢复的关键因素,越早行输尿管再通术,肾脏的功能恢复越好。
Objective To observe the recovery of renal function after ureteral obstruction recanalization at different time points. Methods Twenty-four dogs were randomly divided into 3 groups, and left ureter was ligated to make ureteral obstruction model. Ureteral recanalization was performed on the 1st, 4th and 8th week respectively after obstruction, radionuclide (99mTc-DTPA) imaging was performed before and after the obstruction and 2 weeks and 4 months after the recanalization. Obstructive renal function Resume image changes and calculate glomerular filtration rate. Results In the first week after ureteral obstruction, the renal function of recanalization can be completely restored to normal level. After 4 weeks of recanalization, renal function can only partially recover after 8-week recanalization. Renal function recovery. Conclusions Ureteral obstruction time is the key factor that affects the recovery of canine renal function. The earlier the ureter recanalization, the better the functional recovery of the kidney.