目前认为自身免疫病的发生是由于“自己”与“非己”识别机制被打破所致。对自身抗原耐受的机制主要是胸腺中对自身反应性T细胞的克隆清除。但是,一些自身反应性T细胞也可逃避胸腺的清除,或仅识别胸腺外表达的抗原。T细胞无能或免疫忽视曾经被认为是控制这些具有潜在自身反应性 At present, the occurrence of autoimmune diseases is thought to be due to the breaking of the identification mechanism of “self” and “non-self”. The mechanism of tolerance to autoantigen is mainly clonal clearance of autoreactive T cells in the thymus. However, some autoreactive T cells can also evade thymus clearance, or only identify antigens expressed outside the thymus. T-cell impotence or immune neglect was once thought to control these potentially self-reactive