目的:观察地黄总苷对毒性弥漫性甲状腺肿(GD)小鼠的影响。方法:通过对C57小鼠皮下多点注射猪甲状腺球蛋白(PTG)6 w复制GD模型,将成模小鼠分为模型组、丙硫氧嘧啶(50 mg/kg)阳性对照组及地黄总苷低(30 mg/kg)、中(60 mg/kg)、高(120 mg/kg)剂量组,另设正常对照组。于给药5 w后检测各组小鼠的耗氧量、心率以及脾脏和胸腺指数变化;放射免疫法检测三碘甲状腺原氨酸(T_3)、甲状腺素(T_4)、游离三碘甲状腺原氨酸(FT_3)、游离甲状腺素(FT_4)等指标并对甲状腺组织进行组织病理学检查。结果:与模型组比较,地黄总苷中、高剂量组小鼠耗氧量、心率及血清中T_3、T_4、FT_3、FT_4等指标均显著降低(P<0.05),胸腺指数显著升高(P<0.05)。结论:地黄总苷具有一定改善和治疗毒性弥漫性甲状腺肿的作用。 Objective: To observe the effect of total flavonoids of Rehmannia glutinis on mice with toxic diffuse goiter (GD). Methods: GD model was established by subcutaneous injection of porcine thyroglobulin (PTG) for 6 weeks in C57 mice. The model mice were divided into model group, propylthiouracil (50 mg / kg) positive control group and total flavonoids Low (30 mg / kg), medium (60 mg / kg), high (120 mg / kg) dose group, another set of normal control group. The oxygen consumption, heart rate and spleen and thymus index of mice in each group were detected after 5 weeks of administration. The levels of T_3, T_4, Acid (FT_3), free thyroxine (FT_4) and other indicators of thyroid tissue and histopathological examination. Results: Compared with the model group, the oxygen consumption, heart rate and serum T_3, T_4, FT_3, FT_4 and other indexes in the medium and high dose groups of Rehmannia glutinosa were significantly decreased (P <0.05) and the thymus index was significantly increased <0.05). Conclusion: Rehmannia glycosides have the effect of improving and treating diffuse goiter.