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目的观察肺癌肿瘤抑制因子1(TSLC1)及脆性组氨酸三联体(FHIT)在宫颈癌组织中的表达,并分析其与人乳头瘤病毒(HPV)感染的关系。方法回顾性分析2014年2月-2015年3月在妇产科及门诊患者的临床资料,并根据确诊结果将其分为正常对照组(20例)、宫颈上皮内瘤变(CIN)Ⅰ~Ⅱ组(20例)、CINⅢ组(18例)和宫颈癌组(45例)。观察TSLC1及FHIT在正常宫颈组织、CIN组织和宫颈癌组织中的表达情况,探讨TSLC1及FHIT与宫颈癌临床病理特征的关系,分析TSLC1及FHIT与HPV感染的相关性。结果正常宫颈组织、CIN组织和宫颈癌组织中的TSLC1及FHIT阳性表达率存在明显差别:宫颈癌CINⅢ>CINⅠ~Ⅱ>正常宫颈组织,差异具有统计学意义;HPV感染率与TSLC1、FHIT表达率呈明显负相关关系(P<0.05)。结论 TSLC1及FHIT在子宫癌组织中的阳性表达率较低,且与HPV感染密切相关。
Objective To observe the expression of tumor suppressor 1 (TSLC1) and fragile histidine triad (FHIT) in cervical cancer and to analyze their relationship with human papillomavirus (HPV) infection. Methods The clinical data of obstetrics and gynecology and outpatients from February 2014 to March 2015 were retrospectively analyzed. According to the results of the diagnosis, they were divided into normal control group (n = 20), cervical intraepithelial neoplasia (cIN) Ⅰ ~ Ⅱ group (20 cases), CIN Ⅲ group (18 cases) and cervical cancer group (45 cases). To observe the expression of TSLC1 and FHIT in normal cervical tissues, CIN tissues and cervical cancer tissues, to explore the relationship between TSLC1, FHIT and clinicopathological features of cervical cancer, and to analyze the correlation between TSLC1, FHIT and HPV infection. Results The positive rates of TSLC1 and FHIT in normal cervical tissues, CIN tissues and cervical cancer tissues were significantly different: cervical cancer CINⅢ> CINⅠ-Ⅱ> normal cervical tissue , The difference was statistically significant; HPV infection rate and TSLC1, FHIT expression was negatively correlated (P <0.05). Conclusion The positive rate of TSLC1 and FHIT in uterine cancer tissues is low, and it is closely related to HPV infection.