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应用放射免疫法测定了30例健康人和27例外源性哮喘患者血浆中 TXB_2,6-keto-FGF_(12)水平。结果表明,哮喘患者发作期与缓解期 TXB_2水平、TXB_2/6-Keto-PGF_1α比值均显著增高。6-Keto-PGF_1α水平发作期明显降低。提示哮喘患者存在 TXB_2-PGI_2之间平衡失调。缓解期 TXB_2水平增高可能是哮喘易复发的原因之一。
The plasma levels of TXB_2, 6-keto-FGF 12 in 30 healthy subjects and 27 exogenous asthmatics were measured by radioimmunoassay. The results showed that the TXB_2 level and TXB_2 / 6-Keto-PGF_1α ratio in asthma patients during the attack and remission stages were significantly increased. 6-Keto-PGF_1α levels significantly reduced attack. Tip asthma patients there TXB_2-PGI_2 imbalance between. Elevated TXB_2 in remission may be one of the causes of asthma relapse.