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目的通过对苯接触工人尿中酚和反-反式黏糠酸的监测与分析,开展低苯环境下苯接触生物标志物研究,并探讨其实际应用价值。方法选取某制鞋厂员工作为研究对象,测定其尿液中酚和反-反式黏糠酸浓度,并对作业工人工作场所中苯浓度进行监测。结果接苯工人尿酚浓度与接苯浓度无显著性相关关系,尿中反-反式黏糠酸浓度与接苯浓度存在显著正相关(P<0.05),接苯工人班后尿中的反-反式黏糠酸浓度显著高于班前尿(P<0.05),吸烟对尿酚浓度影响较小,吸烟者尿中反-反式黏糠酸浓度显著高于非吸烟者(P<0.05)。结论低浓度苯工作环境下,尿中反-反式黏糠酸可以作为一种敏感的生物标志物替代尿酚反映机体苯暴露情况。
OBJECTIVE To investigate the biomarkers of benzene exposure in low benzene environment by monitoring and analyzing urinary phenol and trans-trans-muFoI acid in benzene exposed workers, and to explore its practical value. Methods A shoe factory employee was selected as the research object. The concentration of phenol and trans-trans-muconic acid in the urine was measured. The concentration of benzene in the workplace was monitored. Results There was no significant correlation between the concentration of phenol and the concentration of benzene in benzene, and the concentration of trans-trans-muconic acid in urine was positively correlated with the concentration of benzene (P <0.05) - The concentration of trans-muconic acid was significantly higher than that before class (P <0.05). Smoking had little effect on the concentration of urinary phenol. The concentration of urinary anti-trans-muconic acid in smokers was significantly higher than that in non-smokers (P <0.05) ). CONCLUSIONS: Urinary reverse trans-trans-muFoFIC can be used as a sensitive biomarker instead of urool to reflect the body’s benzene exposure in low-benzene working environment.