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目的:通过对儿童噬血细胞综合征患者凝血指标及血小板参数的结果分析,探讨其在儿童噬血细胞综合征中的的临床意义。方法:对儿童噬血细胞综合征患者和健康对照者的凝血酶原时间(PT)、活化部分凝血酶时间(APTT)、凝血酶时间(TT)、纤维蛋白原(FIB)、血小板(PLT)、血小板压积(PCT)、平均血小板体积(MPV)、血小板分布宽度(PDW)指标进行比较、统计学处理。结果:噬血细胞综合征组和健康对照组比较,PT、APTT、TT、PDW、PCT、MPV、PLT检测结果差异有统计学意义(均P﹤0.05),而FIB差异无统计学意义(P>0.05)。结论:噬血细胞综合征临床表现复杂,进展迅速,预后差,病死率高,临床相对少见。由于噬血细胞综合征患者存在低凝状态,故早期检测凝血功能及血小板参数,对指导治疗和改善预后具有重要的临床意义。
Objective: To investigate the clinical significance of hemophagocytic syndrome in children with hemophagocytic syndrome by analyzing the results of coagulation parameters and platelet parameters in children with hemophagocytic syndrome. Methods: The prothrombin time (PT), activated partial thromboplastin time (APTT), thrombin time (TT), fibrinogen (FIB), platelet (PLT) (PCT), mean platelet volume (MPV) and platelet distribution width (PDW) were compared and statistically analyzed. Results: The results of PT, APTT, TT, PDW, PCT, MPV and PLT in hemophagocytic syndrome group were significantly different from those in healthy control group (all P <0.05), but there was no significant difference in FIB (P> 0.05). Conclusion: The manifestations of hemophagocytic syndrome are complex, rapid progress, poor prognosis, high mortality, clinical relatively rare. Because hemophagocytic syndrome patients with low coagulation status, so early detection of coagulation and platelet parameters, to guide the treatment and improve prognosis of important clinical significance.