用杂交瘤技术在国内首次获得了14株分泌抗人血小板单克隆抗体的小鼠杂交瘤细胞株,并将其中两株SZ-2,SZ 21应用于血小板生理和病理的研究。SZ-2单克隆抗体为IgG_1亚类,分子量150,000,PI5.7,只与正常人血小板及巨核细胞特异结合,其识别的抗原决定簇位于血小板膜糖蛋白I_b的α链。与血小板的结合位点数为1.52±0.41×10~4/血小板,KD为0.66±0.33 Fourteen hybridoma cell lines secreting anti-human platelet monoclonal antibodies were obtained in China for the first time by using the hybridoma technique, and two SZ-2 and SZ 21 strains were used for the study of platelet physiology and pathology. SZ-2 monoclonal antibody IgG_1 subclass, molecular weight 150,000, PI5.7, only with normal human platelets and megakaryocytes specific binding, the identified antigenic determinants located in the platelet glycoprotein I_b α chain. The number of binding sites to platelets was 1.52 ± 0.41 × 10 ~ 4 / platelet with a KD of 0.66 ± 0.33