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目的探讨前列地尔与长春西丁治疗急诊眩晕的疗效比较。方法选取我院急诊科就诊的经确诊为椎基底动脉缺血性眩晕的患者60例,采用随机数字表法分为前列地尔治疗组和长春西丁治疗组,疗程7天,治疗前后行经颅多普勒超声(TCD)检查,采用临床疗效以及用药前后双椎、基底动脉的血流平均流速(Vm)和收缩峰值(Vs)的变化情况来进行疗效评定。结果两组患者治疗前后自身比较,双椎、基底动脉的Vm、Vs值改善程度均有显著性差异(P<0.01)。两组患者治疗后,前列地尔治疗组的显效率、有效率、总有效率以及双椎、基底动脉的Vm、Vs值改善程度均显著高于长春西丁治疗组,其差异均有统计学意义(P<0.05)。结论前列地尔与长春西丁治疗急诊椎基底动脉缺血性眩晕均有较好的治疗效果,但前列地尔的效果优于长春西丁。
Objective To investigate the efficacy of prostaglandin and vinpocetine in the treatment of emergency dizziness. Methods Sixty patients diagnosed as vertebrobasilar ischemic vertigo were enrolled in this study. Patients were divided into alprostadil treatment group and vinpocetine treatment group by random number table. The course of treatment was 7 days. Before and after treatment, Doppler ultrasound (TCD) examination, the clinical efficacy and medication before and after the double vertebral, basilar artery blood flow velocity (Vm) and peak systolic (Vs) changes were evaluated. Results Before and after treatment, Vm and Vs in both vertebrae and basilar artery were significantly improved (P <0.01). After treatment, the effective rate, total effective rate and Vm, Vs of both vertebral and basilar artery in the alprostadil group were significantly higher than those in the cetuximab group, the difference was statistically significant Significance (P <0.05). Conclusion Alprostadil and vinpocetine are effective in treating vertebrobasilar ischemic vertigo. However, alprostadil is superior to vinpocetine.